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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes Severe Headaches After An Increase In Duloxetine Dosage?

My doctor increased my dosage of duloxetine last week and since Monday I have been getting worse headaches (I don t normally get headaches at all) and everyday the nausea has gotten worse (I never get nausea). How do I get rid of this feeling and get this out of my system?
Fri, 23 Feb 2018
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Psychiatrist,  's  Response
hi sir /madam
I have gone through your question and understand your concerns

regarding duloxetine: it's an antidepressant drug belonging to SNRI group. it's mostly used for depression and neuropathic pain disorders in diabetes and for urinary incontinence.

it's main side effects being nausea(most common), dry mouth, constipation, dizziness...soon. your present nausea complaint mostly related to duloxetine itself but regarding headache, it may not be due to duloxetine.

regarding dosage : mostly, initial dose is 20mg and recommend effective dose is 60mg per day. greater than that dose, mostly not effective and leads to side effects. but, you didn't provide the dose your using at present an didn't mention your present symptoms for which your using duloxetine.
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What Causes Severe Headaches After An Increase In Duloxetine Dosage?

hi sir /madam I have gone through your question and understand your concerns regarding duloxetine: it s an antidepressant drug belonging to SNRI group. it s mostly used for depression and neuropathic pain disorders in diabetes and for urinary incontinence. it s main side effects being nausea(most common), dry mouth, constipation, dizziness...soon. your present nausea complaint mostly related to duloxetine itself but regarding headache, it may not be due to duloxetine. regarding dosage : mostly, initial dose is 20mg and recommend effective dose is 60mg per day. greater than that dose, mostly not effective and leads to side effects. but, you didn t provide the dose your using at present an didn t mention your present symptoms for which your using duloxetine.