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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes Persistent Elevation In Blood Sugar Levels Despite Taking Metformin And Insulin?

Hi I was just wondering if a person was put on metformin and then insulin and neither seems to help the glucose numbers is it possible the person doesn t have type 1 or 2 diabetis? The Doctors are totally confused here. They first thought it was type 2 than maybe type 1 but neither attemps at lowering the levels is working so ????
Thu, 23 Feb 2017
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General & Family Physician 's  Response
Hello,

I understand your concern. This is a very peculiar case indeed and I am sure the doctors have investigated all the possibilities in order to explain it.
First of all, high glucose levels in the blood is the definition of diabetes, so yes, in this case, you can safely confirm diabetes. Both metformin and insulin would lead to hypoglycemia (low glucose levels in the blood) in a normal or non diabetic person.
In this case it seems blood sugar levels are resistant to treatment and there are only two reasons I can think of. Either the person is taking other drugs that interfere with metformin or insulin effect, such as certain antibiotics, or there is another concomitant condition such as a tumor. In any case, a further investigation is required. I hope this helps.

Wishing you all the best
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What Causes Persistent Elevation In Blood Sugar Levels Despite Taking Metformin And Insulin?

Hello, I understand your concern. This is a very peculiar case indeed and I am sure the doctors have investigated all the possibilities in order to explain it. First of all, high glucose levels in the blood is the definition of diabetes, so yes, in this case, you can safely confirm diabetes. Both metformin and insulin would lead to hypoglycemia (low glucose levels in the blood) in a normal or non diabetic person. In this case it seems blood sugar levels are resistant to treatment and there are only two reasons I can think of. Either the person is taking other drugs that interfere with metformin or insulin effect, such as certain antibiotics, or there is another concomitant condition such as a tumor. In any case, a further investigation is required. I hope this helps. Wishing you all the best