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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes Nausea While On Methotroxate For Rhuematoid Arthritis?

Hi Dr, i have rhuematoid arthritis for the past 5years, i am 37 years old, i have been on sulfasazine, then i had to have methotroxate tablets, i wanted to conceive so i went on prednisolone but no luck. My consultant insisted i go back on methotroxate as i cant stay on steriod for long. So now i am back on methotroxate injections 2.5mg. The only problem is i am always nauseas which i cant stand. It is making me depressed. What can i do?
Mon, 23 Feb 2015
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General & Family Physician,  's  Response
Thanks for posting your question on HCM!
I appreciate your concern regarding the safety of Methotrexate.
Well, vomiting is one of the common side effects seen with the use of Methotrexate. It is assumed that you are taking this injection once in a week is it not? Anyhow the vomiting can be prevented with the use of Ondansetron tablets or injection.
kindly consult your doctor for his opinion and treatment of vomiting.
Best regards.
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Internal Medicine Specialist,  Dr. Tushar Kanti Biswas's  Response
Hi,

Thank you for your query. I can understand your concerns.





Methotroxate can cause gastro-intestinal side effects like Nausea,abdominal distress (common),anorexia,vomiting, diarrhea,Stomatitis/mouth ulcers etc.
You can take preservative-free methotrexate IM or switch over to oral administration 1–2 hr before meals.

Regards

Dr. T.K. Biswas M.D.
Mumbai
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What Causes Nausea While On Methotroxate For Rhuematoid Arthritis?

Thanks for posting your question on HCM! I appreciate your concern regarding the safety of Methotrexate. Well, vomiting is one of the common side effects seen with the use of Methotrexate. It is assumed that you are taking this injection once in a week is it not? Anyhow the vomiting can be prevented with the use of Ondansetron tablets or injection. kindly consult your doctor for his opinion and treatment of vomiting. Best regards.