Hi thanks for asking question. Both SLE and lymphocytic colitis can lead to inflammation of colon.But these both are not interconnected. The etiology of lymphocytic colitis is not clear.Hyperactive immune response can be cause but not well proven.Treatment for it include NSAIDs and steroid like drugs to reduce inflammation. SLE is multisystemic autoimmune disease. It can lead butterfly skin race over face, pleuritis , pericarditis etc along with colitis also. So both these can lead colitis but etilogically not connected. I hope you will understand my concern. Wish you good health.