Hello, * As per my clinical experience, the issue of difficulty in urination with presence of tissue particles in the urine indicates underlying urinary infection most likely. * The difficulty in urination is related to passage of white blood cells in urine through bacterial infection, underlying inflammation of urinary bladder or urethra most likely. * E.coli is the usual bug responsible in majority of the urinray tract infections. * Tissue particles in urine are in concern with the passage of epithelial cells from the bladder wall epithelium mostly. My guidelines at present: - drink plenty of liquids including boiled water, lemon juice, coconut water, barley water, butter milk - cranberry pills or sachets - consume more of citrus fruits as oranges, berries - chewable vitamin C tablets - maintain vaginal hygiene - avoid sexual intercourse if active - avoid prolong use of same vaginal tampons - wipe vaginal area from back to front after wash room use * Consult your doc for evaluation with urine microscopy report and antibiotics prescription with supportive care. Hope I have answered your query. Let me know if I can assist you further. Take care Regards, Dr. Bhagyesh V. Patel