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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes An Elevation In The Blood Sugar Level Despite Taking Glimepiride?

My Dr just started me on glimipiride at 2mg once a day. I started my first dose yesterday morning. My first reading before breakfast was 189 and then 2 hrs after my reading was 238. My reading 2 hrs after lunch was198. My sugar level just before bed was 214. Morning of day 2, my wake up reading is 192. Worried that I can t lower my sugar levels down enough.
Thu, 10 Aug 2017
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Endocrinologist,  's  Response
Hello
I have gone through your question and understood your concern.

Glimepiride is a sulfonylurea antidiabetic medicine. It works by causing the pancreas to release insulin, which helps to lower blood sugar.

I can see that your diabetes numbers with 2 mg Glimepiride are not OK.

You have high fasting and postprandial blood sugar levels and this means that Glimepiride is not effective.
If you take the medication regularly,have a proper diabetes diet and do regular exercise every day this means that the treatement with Glimepiride is not the right choice for you,in this moment.

If you were my patient i will recommend you to continue with this regymen of therapy(glimepiride 2 mg/morning +diet + exercise) for a couple of days,because you just start it yesterday and it is too early to archieve the best results.

If after some days with this therapy you have the same sugar levels ,than i suggest to consult your treating endocrinologist because it is necessary to add another diabetes drug or to start insulin therapy to improve your blood sugar control.

YOu should learn how to live with diabetes.This is very important for you.
My advice is talk to your health care team and learn how to take care of your diabetes.Follow the diet and exercise program given to you by your health care provider.These are elements to manage your diabetes.

Hope this information is helpful.
If you have other doubts,feel free and ask.
Best regards.






Glimepiride should be taken by mouth with breakfast or the first main meal of the day.

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Internal Medicine Specialist,  Dr. Tushar Kanti Biswas's  Response
Your blood sugar is uncontrolled. Glimepiride,2 mg alone is not enough. Metformin 500 mg three times a day can be added by your physician,provided serum creatinine with other oral antidiabetic such as Glimepiride. An extended-release form of Metformin is available and may have fewer gastrointestinal side effects (diarrhea, anorexia, nausea,
metallic taste).
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Note: For further follow-up, discuss your blood glucose reports with our diabetologist. Click here.
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What Causes An Elevation In The Blood Sugar Level Despite Taking Glimepiride?

Hello I have gone through your question and understood your concern. Glimepiride is a sulfonylurea antidiabetic medicine. It works by causing the pancreas to release insulin, which helps to lower blood sugar. I can see that your diabetes numbers with 2 mg Glimepiride are not OK. You have high fasting and postprandial blood sugar levels and this means that Glimepiride is not effective. If you take the medication regularly,have a proper diabetes diet and do regular exercise every day this means that the treatement with Glimepiride is not the right choice for you,in this moment. If you were my patient i will recommend you to continue with this regymen of therapy(glimepiride 2 mg/morning +diet + exercise) for a couple of days,because you just start it yesterday and it is too early to archieve the best results. If after some days with this therapy you have the same sugar levels ,than i suggest to consult your treating endocrinologist because it is necessary to add another diabetes drug or to start insulin therapy to improve your blood sugar control. YOu should learn how to live with diabetes.This is very important for you. My advice is talk to your health care team and learn how to take care of your diabetes.Follow the diet and exercise program given to you by your health care provider.These are elements to manage your diabetes. Hope this information is helpful. If you have other doubts,feel free and ask. Best regards. Glimepiride should be taken by mouth with breakfast or the first main meal of the day.