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Thanks for contacting with your health concern
1. Topiramate is an anticonvulsant drug approved by the FDA in combination with
phentermine for
weight loss. [also used in epilepsy, and prophylaxis of migraine].
2. Your attending Physician must have taken due precautions in prescribing you the medicine, [he must have weighed advantages over side effects], but because topiramate causes loss of calcium through the kidneys and because you have
osteoporosis [very dangerous and serious condition] thus you have to stop taking the same and ask him to prescribe some better alternative to the drug.
3. In a recent journal of Epilepsia. 2011 Oct;52(10):1884-9. doi: 10.1111/j.1528-1167.2011.03131.x. Epub 2011 Jun 21.: "The effect of topiramate monotherapy on bone mineral density and markers of bone and mineral metabolism in premenopausal women with epilepsy" the clinical significance after the trial was:
"use of topiramate is associated with lower
parathyroid hormone and bicarbonate concentrations along with mild
hypocalcemia and increased bone turnover, which suggests that topiramate may have long-term effects on bone.