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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What are the long term side effects of Gardenal and Eptoin syrup?

My daughter (Aged 18 months) have had two episodes of unresponsiveness (lasting for less than 1 minute). We consulted Dr. Lokesh Lingappa of Rainbow Hosp in Hyd. He advised EEG which revealed- Focal slowing bilateral occipital region (This sleep EEG record showed the background activity consists of symmetrical and synchronous 6-7Hz activity with amplitudes of 40-60uV. There are movement artifacts are noted. There are high voltage sharp and slow wave activity noted over bilateral occipital region with amplitude of upto 300uV.) Blood Report: Calcium- 9.6 mg/dl; Phosphorus- 7.3 mg/dl; Electrolytes(Specimen: Serum): Sodium 14o mmol/l; Potassium- 4.3 mmol/l; Chloride- 103 mmol/l There have been some behavioral changes in her like- becoming quiet at times, not responding when we call her, gives blank looks at times; have become less active; rubs her eyes; looks up at the ceiling/sky... Her doc further advised a Brain MRI if it happens again. After the last episode i.e. on 14th Jan, it has not repeated. Her doctor has prescribed Syrup- Gardenal - 3.5 ml twice a day) whereas NIMHANS has prescribed Syrup- Eptoin (5ml- once a day). Please advise which of these two medicines is going to be safe for her and whether there is any other line of treatment available. Is it curable and whether there would be any long-term side effects of these medicines?
Wed, 1 Jul 2020
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General & Family Physician 's  Response
Hi,

Long term side effects of Phenytoin and Phenobarbital can include:
Moodiness / irritability
Confusion
Insomnia
Impaired judgment
Memory problems
Increased aggression
Blistering on the extremities
Enzyme induction and drug pharmaco kinetic changes and interaction
Hepatic failure etc.

Take care. Hope I have answered your question. Let me know if I can assist you further.

Regards,
Dr. Ajeet Singh, General & Family Physician
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What are the long term side effects of Gardenal and Eptoin syrup?

Hi, Long term side effects of Phenytoin and Phenobarbital can include: Moodiness / irritability Confusion Insomnia Impaired judgment Memory problems Increased aggression Blistering on the extremities Enzyme induction and drug pharmaco kinetic changes and interaction Hepatic failure etc. Take care. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Ajeet Singh, General & Family Physician