Thankyou for writing to HCM! From your question it looks that your husband has a psychotic illness, he is on depakote sprinkles and resperidone 3 mg but still has suspiciousness and talks out of context. dosage of depakote is not mentioned. from my clinical experince I can say that either the dosage of the medicine is low or may be he is not taking it regularly. so, if you are sure of compliance, it will be very helpful to increase th dose of resperidone to 4mg - 6mg in a day. along with it , I have seen colonazepam 0.5-1 mg effective in case when patient is difficult to manage /gets very angry/unable to sleep, on as and when required basis. It is advisable to get sodium valproate levels done, to ensure that the sprinkles are providing adequate amont of drug in body or not. Please donot loose hope, it is not at all difficult to manage such cases, what is needed is dose adjustment and make sure he takes the medicine daily and he will start behaving normally once again. You have said that your husband developed this illness after he was given date rape drug, and he has the memory lapse of that time. Well, it is rather difficult to say that one time use of that drug lead to his disorder, it appears more of a coincidence. Althemore, it has no effect over his managment, so, even if it is, giving medication will solve the problem. While the patient is on resperidone, it is advisable to check for increased salivation or some kind of involuntary movements, rigidity of limbs, they may occur develop due to drug. if it does happen, let your doctor know. these are totally curable. please see a psychiatrist nearby and discuss the problem and get the blood levels done. Hope the answer helps you feel free to ask more queries. Dr. Mnaisha Gopal