Hello dear Greetings Regarding your husband symptoms of difficulty in breathing I am suggesting the following differential diagnosis Congestive heart failure Chronic obstructive pulmonary disease Acute chest syndrome Bronchial ashma Please let him check his blood pressure and do the following test Chest x-ray ECG EKG Pulmonary function test Meanwhile see cardiologist specialist with the result further clinical assessment and adequate drug prescription Following his experience of pressure behind the eyes I am suggesting a possibility of developing a glaucoma Let him see an ophthalmologist specialist for expert management I hope this helps