Hello. Thanks for writing to us at healthcaremagic Herpes is a localized infection and it can certainly be transmitted by close physical contact. Condoms provide only partial protection against transmission because they cover only the shaft of the penis and don t cover the base of the penis and pubic region. Therefore a herpes lesion e.g on the base of penile shaft or pubic region can still be transmitted between sexual partners due to direct contact during sex. Once daily valacyclovir reduces the rate of viral replication and also clinical herpes and therefore makes the person less infectious or less likely to give herpes to sexual partner. However the risk is not completely zero even with valacyclovir. Currently there is no other method such as you mention e.g spray, that can reduce risk of transmission. As a precaution you must avoid sexual contact during clinical episodes when there is a high risk of transmitting the virus. A condom does reduce the risk as does Valacyclovir, but they don t make it to Zero Regards