Everybody is built differently. There are some people who respond to the medicines immediately, and others that are sometimes put on 2 types of medicines 2 to 3 times a day to try to control blood pressure. I have met people who have been on blood pressure medicine for years and they still are having trouble getting it under control. Try to be patient, it takes a bit of experimenting to get the right combination down. There is an outside chance, after you have exhausted all the doses and combinations of meds, that a renal angiogram might show a stenosis in the renal artery. If a renal artery stenosis is found in either the right or left kidneys, sometimes a stent to open the artery will bring the blood pressure back under control. I have seen some patients who have had this done and their blood pressure goes down, and I have seen others have it done with no success. I say try this as a last resort because it is an invasive procedure. The doctor has to put a catheter into the femeral artery and run it up to the renals. It is done routinely every day, but there are some risks. Good luck.