78 yr old Female c hx of hypotension , ulcerative colitis , TIA, DVT , kidney cancer resulting in removal of 1 kidney, subsequent CKD stage for with 20% function remaining. 6 days ago arrived in ICU due to abscess size of twinkie in rectum. Primrose in place to facilitate drainage. Sepsis with postivite resistant staph hominis. Tx with doxycycline and clindamycin. Intubated x3 days to prevent ALI, now on SIMV. No hypoxic events. Sedated with ativan and morphine. Off sedation for 25 hours with still no movement. Kidney function still adequate, WBC now 9,000. Lungs clear, liver function good. TPN to rest gut. Why has she not awakened?