I once had a false positive on my drug screen from taking Diphenhydramine/Benadryl/Sominex. It showed up as methadone and initially, I had no idea why I tested positive. We figured it out by process of elimination and what had changed with my meds. I had started taking Sominex instead of Ambien. Thankfully, the confirmation test they send out, cleared things up but I want to avoid anything like that in the future. I have MS and several ruptured discs and have been in pain mgmt for years and have never failed a drug screen until this. I take any and all med exactly as prescribed so that false positive incident scared me to death. I was fearful that a lab error was going to ruin my life and the trust with my dr. Anyway, I have a new dr.and haven tbeen sleeping well so I took some Sominex again. I have a monthly routine urine screen coming up on the 8th. Do I need to mention this to the Dr BEFORE I do the screen. I m afraid I will sound suspicious and like I m making up an excuse in case I test positive for methadone. I know that a confirmation test would once again, clear up the matter and would be negative but I don t want the trust to be compromised during that waiting period and I don t even know if my new dr.does confirmation testing or if he would fire me on the spot for a failed screen. I take great care to make sure I do everything as prescribed and I don t even want to take the chance of my new dr questioning my honesty. The best thing would just be to have the confidence that no DiphenhydramineIis in my system when I take the urine screen. How long before the screen should I stop taking it to make sure there Iis no question. In other words, how long will it remain in my system