Hi, The fatigue tends to not get worse and to level out. I don t know what to say about pain issues. Most drugs for treatment of pain cause fatigue. Disk disease has to be monitored that it doesn t cause paraplegia. If it doesn t cause nerve damage, then, mostly the same way that muscles, joints, skin sag with being old, the internal structures also sag. This produces the lumbar disk paradox of the disk getting further out of place over age, but the need for narcotics decreasing because the disk and the other structures have more space. Fibromyalgia responds well to modalities to increase pain tolerance (exercise, mobility, meditation, and physical therapy). Hope I have answered your query. Let me know if I can assist you further. Regards, Dr. Matt Wachsman, Addiction Medicine Specialist