Hi Dr. Sudhir Sir, I am wife of Manjunath your patient, who was suffering from bipolar disorder/depression and taking treatement of sizdon plus, pacitane, then respond plus pacitane and arip 15mg and pacitane form 2013, he had stopped the medicine form October 2016 and got severe symptoms suddenly this sunday like smiling and hearing voices from within, sleeplessness, not ging to office, I had took him to near by Dr Kapur in Columbia asia as we are staying in hebbal and e was not at all willing to go to any doctor I could just drag him there, Dr Kapur prescribed the following on Tuesday: pactiane 2mg 1-1-0 Clonotril half-half-half Arip 5mg 0-0-1 Sizdon plus 0-0-1 but even today his condition is not improved and still not goin to office, he is still smiling and feels out of world. (he is the same patient who is java programmer and had allegations agaianst his mother in law)