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Have migraine, menopausal, weight gain. Taking zonisamide. Done acupuncture. Reason?

I have been taking zonisamide 100mg daily for 4 years and bus par 20mg daily for the same length of time for migraine treatment and prevention. I am thrilled to report that I have experienced a reduction in my migraines by about 75%. I am also receiving acupuncture several times a month as part of my treatment. So the good news is that I am able to function with greater consistency but I have gained 30 pounds and experience memory issues. The extra weight is really making me uncomfortable and I have been walking and limiting my diet to no avail for several months. I just continue to consistently gain a couple of pounds each month. I am 53 years of age so I imagine that menopause is also playing a role. I am considering reducing or eliminating one or both of the medications because I just do not feel right . I do not want to open the flood gate to the migraines but the excessive weight gain is making me feel uncomfortable and unhealthy in other ways. I think that I should eliminate the zonisamide to begin the process and do so methodically - bring down the dose. I am currently working full time and going to graduate school so the buspar is helping me to manage the stress which is most definitely a headache trigger. Just wondering if I am headed in the right direction ?
Asked On : Tue, 26 Feb 2013
Answers:  2 Views:  42
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Psychiatrist 's  Response
Hi there, thanks for asking. As far as I know zonisamide may cause lack of appetite, but it is far that it cause increase in your appetite. I recommend you have more physical activity and manage your menopausal syndrome to manage your weight. Best wishes.
Answered: Wed, 4 Sep 2013
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Neurologist Dr. Sudhir Kumar's  Response
Nov 2013
Thank you for posting your query.

I am glad to note that your migraines are better with treatment, and you are able to function almost normally.

Weight gain is a lesser problem than migraine. I would agree with your approach of trying to reduce the dose of zonisamide in a gradual manner. This would ensure that there is no relapse of migraine while tapering the medication.

Other option is to use topiramate for migraine prevention. It has a side effect of weight loss, which could work in your favor!

I hope it helps.
Please get back if you require any additional information.

Best wishes,

Dr Sudhir Kumar MD (Internal Medicine), DM (Neurology)
Senior Consultant Neurologist
Apollo Hospitals, Hyderabad,
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Answered: Wed, 4 Sep 2013
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