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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Does thioredoxin reductase help in treatment of cancer?

my sister has been battling cancer. First she had cervical cancer. She had radiation and surgery and was in the clear. months later the cancer had metastisized into 3 masses in her lower body near the site of the original tumor. chemotherapy has proven ineffective. the doctors have basically said there is nothing they can do. they have stopped chemo and now have her on a drug to stop blood flow to the tumors to help prolong her life. I have read that thioredoxin protects the cancer cells from chemotherapy and radiation. I have also read some publications about thioredoxin reductase as a cancer treatment. do you have any information on this subject and can you suggest any clinics specializing in thioredoxin reductase. I have also read there is a link to the gene p53 as a tumor suppressor.
Fri, 24 Jul 2015
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Radiologist 's  Response
Hi,
Thanks for writing in.

Research shows that redox-sensitive signaling factors such as thioredoxin reductase-1 (TR) and thioredoxin (TRX) may represent central pro-survival factors that would allow tumor cells to evade the damaging and potentially cytotoxic effects of endogenous and exogenous agents that induce oxidative stress.

There have been clinical trials which have shown that thioredoxin reductase inhibitors like arsenic trioxide might have role in treatment of cancer. It is important to know your location so that we might suggest you a hospital where this treatment is provided. Please contact your national cancer network as they might have details. Please do not worry.
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