Hi, Dulcolax L is a combination of two drugs, levonorgestrel and ethinyl estradiol, commonly used as a contraceptive pill to prevent pregnancy. In your case, it is being prescribed to control endometriosis and regulate menstrual cycles. Long-term use of Duoluton L tablets can have side effects, including: * Increased risk of blood clots and strokes: The estrogen component in the pill can increase the risk of blood clots and strokes in some women, especially those who smoke, have obesity, or a history of blood clotting. * Nausea and vomiting: Some women may experience nausea and vomiting when taking the pill. * Changes in menstrual cycle: The pill can cause changes in the menstrual cycle, including lighter or heavier bleeding or missed periods. * Mood changes: Some women may experience mood changes, such as depression or anxiety, when taking the pill. * Breast tenderness: The pill may cause breast tenderness or enlargement. It is important to discuss any concerns about the long-term use of Duoluton L tablets with your doctor. They may recommend alternative treatments or a different dosage to minimize the risk of side effects. Take care. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Priyanka, General & Family Physician