Thank you... my friend was prescribed predisnone for poison ivy almost two years ago... it is making him ill, losing his eye sight, purple bruises all over, his skin is so thin it breaks easily.. He is 55, smokes, is being treated now for hypertension, has panic attacks, depression, stomach problems, all these sound to me like they might be caused by long-term predisnone??? Could this be possible? He has horrible rash on his hands and arms, elbows, never had that before either.. it won t go away even with all this predisnone in his system. Is there something else he could use, or should he be taken off of it completely? I m very concerned about his overall health. Thanks again. Mary Brown