Hi ! Thank you for posting your questions here. I would give you some information about the possible interaction between these drugs and what to look for .Here they are : - Amiodarone - warfarin : amiodaron increase warfarine efect and the patient may be bleeding , be aware of this sign :bruising,any bleeding, blood in urine or stools,headache ,vomiting,dizziness ,weakness. The patient has to check INR every 6month . - Amiodaron- simvastatine: Amiodaron increases the blood levels of simvastatine in result increase the risk of the side effect of simvastatine -liver damage and muscle damage leading to a condition that we call rhabdomyolisis and kidney problems .Be aware of these symptoms;: muscles pain or joint pain,tenderness , weakness ,nause , vomiting , dark urine,yellow skin or eyes.The patient should check the liver and muscles every 6 months. -Amiosarone -trazodone ; can increase the chances of iregular heart beat but is very rare. Amiodaron alone has many side effect: hypersensitivity pneumonitis( problem breathing ,cough,) , blurred vision , photosensitivity ,a halo in the eyes( microdeposition in the cornea), hypotension, hypothyroidism . Make sure that the patient controls the liver , heart ,muscles , thyroid, lungs , INR , every 6 months .If you see any of the symptoms that I mentioned above call the treating doctor. Wish these help. If you have any other questions please feel free to ask me .