Hello and welcome to Healthcare Magic. Thanks for your query. I m sorry to hear that your anxiety and depression problems are persisting despite trying different anti-depressants. Though a majority of people respond well to anti-depressant medication, there can be a smal proportion of people who do not have an adequate response. Usually in such treatment-resistant cases, the management approach first involves investigating for any causes for treatment resistance. Common causes include recurrent or ongoing stress, personality issues, or even certain medical causes, like thyroid problems, certain vitamin deficiencies, etc., which can cause treatment resistance. These complicating factors have to be looked into and treated appropriately, in order to improve treatment outcome. Don t get frustrated or dejected since there are still many treatment options available, like trying a combination of anti-depressants, thyroxine supplementation, augmentation the anti-depressant / anti-anxiety medication with other psychiatric medication like an anti-psychotic or a mood-stabilizer, etc. When medication is ineffective, psychological therapies like Cognitive Behaviour Therapy (CBT) can also be effective. Regarding, your query about brain scans . imaging techniques, you must understand that these are only diagnostic instruments and have no therapeutic role. However, there are certain treatment methods like Transcranial Magnetic Stimulation (TMS), which can be effective in treating depression. So, I would advise you to discuss further treatment options with your psychiatrist. Best wishes, Dr. Sheeba Stephen