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What Is The Treatment For High Grade B Cell Non-Hodgkin's Lymphoma Of The Pancreas With Duodenal Infiltration?

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Posted on Sat, 10 Apr 2021
Question: My Brother is diagnosed with HIGH GRADE "B" CELL NON HODGKINS LYMPHOMA OF PANCREAS with DUODENAL INFILTRATION. I would like to know the
1. treatment we are taking is correct or not and how serious is the situation.
2. Currently we are showing to a medical oncologist, Is it fine or do we need to visit hemato oncologist .
3. Recommendations for any hospital in south XXXXXXX
doctor
Answered by Dr. Deepak Sundriyal (56 minutes later)
Brief Answer:
Hello. Treatment is correct.

Detailed Answer:
Hello dear. I have seen the reports. O would like to
Add few points.
Cd 20 negative b cell lymphoma is a rare entity.
Biopsy should be re confirmed by another pathologist.
If it is again confirmed that it is b cell lymphoma, then same treatment can be continued, as treatment is alright.
Alk negative cd 20 lymphoma is aggressive and prognosis is guarded.
Ttreatimg doctor need not to be changed.
Thanks and regards
Feel free to ask further.
Above answer was peer-reviewed by : Dr. Nagamani Ng
doctor
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Follow up: Dr. Deepak Sundriyal (2 hours later)
Very much thank you for your immediate response. Can you please give more insight on the comment you made

"Alk negative cd 20 lymphoma is aggressive and prognosis is guarded"

Once again thank you very much for quick and clear explanation.
doctor
Answered by Dr. Deepak Sundriyal (10 minutes later)
Brief Answer:
Hello. It means disease biology is bad

Detailed Answer:
Hello dear. Lymphoma which are alk negative and cd20 negative have poor prognosis. Although they respond to chemotherapy well, they have high chances of relapses.
Thanks and regards
Above answer was peer-reviewed by : Dr. Remy Koshy
doctor
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Follow up: Dr. Deepak Sundriyal (21 minutes later)
Thank you sir,

1) Do we have any precautions that need to be taken to avoid relapses.
2) From the reports, Do we know stage of the Cancer?
3) How many Chemo's need to be done ?
4) We have not done the PET scan, Do you suggest PET scan?
5) We have given the second chemo last week, After which he got fever, cold, cough and he is feeling too much fatigue. Is these expected? Feeling very much feared.

I am sorry, I am asking multiple questions.


doctor
Answered by Dr. Deepak Sundriyal (37 minutes later)
Brief Answer:
Hello. Relapse cant be prevented

Detailed Answer:
Hello dear. Relapse cant be prevented if it is bound to happen despite optimum treatment.
Stage of the disease cant be determined as only ct abdomen report is available. However, it is not going to change the line of treatment.
6 cycles of chemotherapy needs to be done.
You can get a pet scan done just prior to next cycle of therapy to know the stage of disease.
Fever and cough are signs of infection. That may occur during chemotherapy as patients of cancer have low immunity.
Prophylactic antibacterial antiviral and antifungal drugs can be added to prevent infection. You can discuss these with your doctor.
Thanks and regards
feel free to ask further queries.
Note: Do you have more questions on diagnosis or treatment of blood disorders? Ask An Expert/ Specialist Now

Above answer was peer-reviewed by : Dr. Remy Koshy
doctor
Answered by
Dr.
Dr. Deepak Sundriyal

Oncologist

Practicing since :2005

Answered : 1617 Questions

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What Is The Treatment For High Grade B Cell Non-Hodgkin's Lymphoma Of The Pancreas With Duodenal Infiltration?

Brief Answer: Hello. Treatment is correct. Detailed Answer: Hello dear. I have seen the reports. O would like to Add few points. Cd 20 negative b cell lymphoma is a rare entity. Biopsy should be re confirmed by another pathologist. If it is again confirmed that it is b cell lymphoma, then same treatment can be continued, as treatment is alright. Alk negative cd 20 lymphoma is aggressive and prognosis is guarded. Ttreatimg doctor need not to be changed. Thanks and regards Feel free to ask further.