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What is lethal plasma level for xanax, benadryl,hydrocodone and oxycodone?

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Allergist and Immunologist
Practicing since : 1999
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The doctor I work for needs to know the lethal plasma level for xanax, benadryl,hydrocodone, oxycodone, oxymorphone,lyrica at different dose levels for all these drugs.
Posted Thu, 27 Feb 2014 in Medicines and Side Effects
Answered by Dr. Sujoy Khan 1 hour later
Brief Answer: Combinations of drugs more lethal than single Detailed Answer: Hello XXXXXXX Welcome to Healthcare Magic. I will provide you the documented lethal levels of the drugs and the source in brackets: Xanax (Alprazolam) - therapeutic range 0.025-0.102 mg/L; fatalities occur at 1.2-7.1 times therapeutic levels; upto 22-90 times blood levels have been recorded [J Anal Toxicol 1997] Benadryl Probable oral lethal dose 50-500mg/kg Toxic levels 5000ng/ml [Oxford Journals 2012] Hydrocodone Lethal level 0.1mg/L Oxycodone Lehal level 0.6mg/L Oxymorphine - not sure but Oxycodone - lethal level 0.6mg/L Lyrica or Pregabalin Pregabalin reaches a peak plasma concentration (means range from 0.04 to 9.5 ug/mL) within 1.5 hours. Following single-dose (25-300 mg) and multiple-dose (75-900 mg/day) administration, maximum plasma concentrations increase linearly, with steady-state levels reached within 24 to 48 hours. The Los Angeles County Department of Coroner Toxicology Laboratory has analyzed casework with postmortem blood levels ranging from 2.7 to 22 ug/mL. Best Wishes.
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