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Dr. Andrew Rynne
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Dr. Andrew Rynne

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What does this blood report indicate?

Answered by
Dr.
Dr. Panagiotis Zografakis

Internal Medicine Specialist

Practicing since :1999

Answered : 3675 Questions

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Posted on Tue, 6 Sep 2016 in Medicines and Side Effects
Question: Hello Doctor:
I was wondering if you could help me interpret the following results from a recent bloodtest:
Epstein Barr:
EBV Viral Capsid AG (VCA) AB IGG: 2.80
EBV Viral Capsid AG (VCA) AB IGM: ,OR=0.90
EBV Nuclear AG (EBNA) AB (IGG) Value .5.00


Varicella Zoster Virus ,OR= 0.90 index

Herpesvirus 6 IGM <1.20
Herpesvirus 6 IGG 1:40

I have been struggling with some health difficulties- in particular a nerve issue (burning mouth syndrome) and my doctor wished to rule out any of the above issues. I'm not sure how to interpret the (relatively) high levels for the EBV virus. Does this just indicate that I've had in infection in the past? (Had a very bad, uncharacteristic tonsil infection in January- have wondered)

Also- the relative lack of antibodies for the herpes virus? I had chicken pox as a child. Looking into a possible non rashing form of shingles-- so this confused me as well,.
Thank you sincerely for your time
XXXXX
doctor
Answered by Dr. Panagiotis Zografakis 22 minutes later
Brief Answer:
Please upload the report

Detailed Answer:
Hello,

I'll be glad to help you interpret the results. Please upload the full report. The lab's normal range of values for the tests is important. Different labs may use different methods to test for the same antibodies...

You can upload it as a picture either by using this website's interface or by uploading it somewhere else and providing me the link.

I'll be waiting for your input.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
default
Follow up: Dr. Panagiotis Zografakis 10 minutes later
Hi
I am hoping this works--I also attempted to upload the pdf.

Test NamePARVOVIRUS B19 ANTIBODY (IGG), PARVOVIRUS B19 ANTIBODY (IGM), EPSTEIN BARR VIRUS ANTIBODY PANEL, CYTOMEGALOVIRUS ANTIBODY (IGG), CYTOMEGALOVIRUS ANTIBODY (IGM), VARICELLA ZOSTER VIRUS ANTIBODY (IGM), VARICELLA ZOSTER VIRUS ANTIBODY (IGG), MYCOPLASMA PNEUMONIAE ANTIBODY (IGG), MYCOPLASMA PNEUMONIAE ANTIBODY (IGM), HERPESVIRUS 6 ANTIBODIES (IGG,IGM), CHLAMYDOPHILA PNEUMONIAE AB (IGG,IGA,IGM) Collection Date08/09/2016Patient NameBallenger, XXXX
View Full Report Not all lab result data may be available on this page. Download the full report for a complete set of results. Hide Details
Out of Range (5)
PARVOVIR... 5.25 Description Graph
IgG persists for years and provides life-long immunity.
To diagnose current infection, consider Parvovirus
B19 DNA, PCR.
Reference Range
<0.9 Negative
0.9-1.1 Equivocal
>1.1 Positive
EBV NUCL... >5.00 Description Graph
Value Interpretation
----- --------------
< or = 0.90 Negative
0.91-1.09 Equivocal
> or = 1.10 Positive
EBV VIRA... 2.80 Description Graph
Value Interpretation
----- --------------
< or = 0.90 Negative
0.91-1.09 Equivocal
> or = 1.10 Positive
VARICELL...
< OR = 0.90 (Ideal Range 1.1 )
Description Graph
Index Explanation of Results
--------- ----------------------
< or = 0.90 Negative - No VZV IgG Antibody detected
0.91 - 1.09 Equivocal
> or = 1.10 Positive - VZV IgG Antibody detected

A positive result indicates that the patient
has antibody to VZV but does not differentiate
between infection (active or past) and vaccination.
The clinical diagnosis must be interpreted in
conjunction with the clinical signs and symptoms of
the patient. This assay reliably measures immunity
due to previous infection but may not always be
sensitive enough to detect antibodies induced by
vaccination. Thus, a negative result in a vaccinated
individual does not necessarily indicate
susceptibility to VZV infection.
MYCOPLAS... 0.99 Description Graph
A positive result indicates that the patient has
antibody to Mycoplasma. It does not differentiate
between an active or past infection. The clinical
diagnosis must be interpreted in conjunction with
the clinical signs and symptoms of the patient.
Reference Range
Negative: < or = 0.90
Equivocal: 0.91-1.09
Positive: > or = 1.10
Additional Results (8)
INTERPRETATION:
Description Graph
Suggestive of a past Epstein-Barr virus infection.
In infants, a similar pattern may occur as a result
of passive maternal transfer of antibody.
HERPESVIRUS 6 IGG
1:40
Description Graph
INTERPRETATION
PAST INFECTION
Description Graph
REFERENCE RANGE: IgG <1:10
IgM <1:20

Human Herpesvirus 6 (HHV-6) infects T-lymphocytes,
and has been identified as an etiologic agent of
exanthema subitum. Rises in antibody titers to
HHV-6 have been detected during infection with
other viruses. In seroepidemiology studies of the
prevalence of exposure using serum screening
dilutions of 1:10, the detection of IgG antibody
in a mid-life population approaches 100%. Due to
this high prevalence of HHV-6 antibody,
correlations of single IgG titers with specific
diseases are of little clinical value.

Evidence of acute infection or reactivation of
HHV-6 is demonstrated by a significant rise or
seroconversion of IgG and IgM titers.

This test was developed and its analytical performance
characteristics have been determined by Focus Diagnostics.
It has not been cleared or approved by the U.S. Food and
Drug Administration. The FDA has determined that such
clearance or approval is not necessary. This assay has
been validated pursuant to the CLIA regulations and is
used for clinical purposes.
HERPESVIRUS 6 IGM
<1:20
Description Graph
C. PNEUMONIAE IGG
<1:64
Description Graph
CHLAMYDOPHILA PNEUMONIAE AN...
<1:10
Description Graph
C. PNEUMONIAE IGA
<1:16
Description Graph
INTERPRETATION
Description Graph
ANTIBODY NOT DETECTED

REFERENCE RANGE: IgG <1:64
IgA <1:16
IgM <1:10

The immunofluorescent detection of specific
antibodies to Chlamydophila pneumoniae may be
complicated by crossreactive antibodies,
non-specific antibody stimulation, or past
exposure to similar organisms such as C. psittaci
and Chlamydia trachomatis. IgM titers of 1:10 or
greater usually indicate recent infection, and any
IgG titer may indicate past exposure. IgA is
typically present at low titers during primary
infection, but may be elevated in recurrent
exposures or in chronic infection.

This test was developed and its analytical performance
characteristics have been determined by Focus Diagnostics.
It has not been cleared or approved by the U.S. Food and
Drug Administration. The FDA has determined that such
clearance or approval is not necessary. This assay has
been validated pursuant to the CLIA regulations and is
used for clinical purposes.
In Range (6)
PARVOVIR...
<0.9
Description Graph
Results from any one IgM assay should not be used as a
sole determinant of a current or recent infection.
Because IgM tests can yield false positive results and
low levels of IgM antibody may persist for months post
infection, reliance on a single test result could be
misleading. If an acute infection is suspected, consider
obtaining a new specimen and submit for both IgG and IgM
testing in two or more weeks. To diagnose current
infection, consider parvovirus B19 DNA,PCR.
Reference Range
<0.9 Negative
0.9-1.1 Equivocal
>1.1 Positive
EBV VIRA...
< OR = 0.90
Description Graph
Value Interpretation
----- --------------
< or = 0.90 Negative
0.91-1.09 Equivocal
> or = 1.10 Positive
CYTOMEGA...
< OR = 0.90
Description Graph
Value Interpretation
----- --------------
< or = 0.90 Negative
0.91-1.09 Equivocal
> or = 1.10 Positive

A positive result indicates that the patient has
antibody to CMV. It does not differentiate between
an active or past infection.
CYTOMEGA...
<0.2
Description Graph
Results from any one IgM assay should not be used as a
sole determinant of a current or recent infection.
Because an IgM test can yield false positive results and
low level IgM antibody may persist for more than 12
months post infection, reliance on a single test result
could be misleading. Acute infection is best diagnosed
by demonstrating the conversion of IgG from negative to
positive. If an acute infection is suspected, consider
obtaining a new specimen and submit for both IgG and IgM
testing in two or more weeks.
Value Interpretation
----- --------------
< or = 0.8 No Antibody Detected
0.9 - 1.0 Equivocal
> or = 1.1 Antibody Detected
VARICELL...
< OR = 0.90
Description Graph
Value Interpretation
----------- --------------
0.00-0.90 Negative
0.91-1.09 Equivocal
>=1.10 Positive

Results from any one IgM assay should not be used
as a sole determinant of a current or recent
infection. Because an IgM test can yield false
positive results and low levels of IgM antibody may
persist for more than 12 months post infection,
reliance on a single test result could be misleading.
If an acute infection is suspected, consider
obtaining a new specimen and submit for both
IgG and IgM testing in two or more weeks.
MYCOPLAS...
<770
Description Graph
Reference Range
Negative: <770
Low Positive: 770-950
Positive: >950
Quest DiagnosticsCONTACT US
doctor
Answered by Dr. Panagiotis Zografakis 10 minutes later
Brief Answer:
worked fine!

Detailed Answer:
I got the uploaded file which contains all the required information.
All your tests are negative for current infection. The positive results only suggest past infections. Some tests are not useful for the evaluation of current infection (antibodies for Mycoplasma for example).

So regarding your first question about Epstein-Barr virus: the result suggests past infection.
Regarding your other question about varicella zoster virus (which causes chickenpox) it's negative like if you've never come into contact with it. Sometimes the antibodies may get lower than the diagnostic threshold despite past infection or the test may not detect them. The immunity is supposed to be life-long though, so if you're certain about the past event (the diagnosis of chickenpox) then you're not supposed to get chickenpox ever again.

I hope it helps!
Kind Regards!
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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