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What Do These Following Lab Reports Indicate?

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Posted on Sat, 23 Jan 2016
Question: I haven't been well in quite some time. My home has had several issues which has caused toxic mold to be present. I ordered a Lyme Ab/Western Blot, Serum test. The results: Lyme Disease Ab, Quant, IgM 1.00 HIGH Ref Range 0.00-0.79 IgG P41 Ab. Present ABNORMAL IgG P39 Ab. Present ABNORMAL. I was told I don't have Lyme Disease. Considering I don't feel well, and these are out of range. What could this possibly mean? Is there treatment for this?
doctor
Answered by Dr. Panagiotis Zografakis (4 hours later)
Brief Answer:
probably nothing...

Detailed Answer:
Hello,

there are certain diagnostic criteria for the laboratory diagnosis of Lyme disease with Antibodies/Western Blot. The patients usually have to undergo an antibody testing (which is more sensitive) and if they're positive they have to do the Western Blot (which is more specific).

The IgM Western Blot test is considered positive if 2 out of the following 3 bands are positive: 23,39 and 41. An IgG test is positive if 5/10 are positive: 18,23,28,30,39,41,45,58,66,93.

Please also note that patients with a long standing syndrome resembling of Lyme disease should have IgG positive too. IgM only after a couple of months of feeling sick means that Lyme disease can be reasonably excluded.

The way you've presented the information, leaves me some doubt about the results so if you'd like me to comment on them, please upload the full report. If the information I've presented to you are sufficient to answer your question, then that's fine too! If the result is negative indeed (and if the lab says it's negative then they should know!), then obviously no treatment can be given.

I hope you find my comments helpful!
You can contact me again, if you'd like any clarification or further information.

Happy New Year!
Note: For more detailed guidance, please consult an Internal Medicine Specialist, with your latest reports. Click here..

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Panagiotis Zografakis

Internal Medicine Specialist

Practicing since :1999

Answered : 3810 Questions

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What Do These Following Lab Reports Indicate?

Brief Answer: probably nothing... Detailed Answer: Hello, there are certain diagnostic criteria for the laboratory diagnosis of Lyme disease with Antibodies/Western Blot. The patients usually have to undergo an antibody testing (which is more sensitive) and if they're positive they have to do the Western Blot (which is more specific). The IgM Western Blot test is considered positive if 2 out of the following 3 bands are positive: 23,39 and 41. An IgG test is positive if 5/10 are positive: 18,23,28,30,39,41,45,58,66,93. Please also note that patients with a long standing syndrome resembling of Lyme disease should have IgG positive too. IgM only after a couple of months of feeling sick means that Lyme disease can be reasonably excluded. The way you've presented the information, leaves me some doubt about the results so if you'd like me to comment on them, please upload the full report. If the information I've presented to you are sufficient to answer your question, then that's fine too! If the result is negative indeed (and if the lab says it's negative then they should know!), then obviously no treatment can be given. I hope you find my comments helpful! You can contact me again, if you'd like any clarification or further information. Happy New Year!