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What Do The Following Blood And Scan Reports Indicate?

Posted on Fri, 26 Jun 2015

Question: Hello sir ,
i have gone through blood test and scanning.

HBSAG = Positive (CMIA Method) 1.35 (>= 0.05 reactive)
HBSAG = NEGATIVE (ELISA Method) < 0.10
HBeag = NEGATIVE
Total antibodies to Hepatits B Core antigen(HBctotal)[CMIA] = Reactive(1.90) (>= 1.0 is reactive)

HEPATITIS B CORE ANTIBODY - (IgM) (Anti-HBc IgM) (ELFA) = Negative (0.01)

HEPATITIS B SURFACE ANTIGEN (HBsAg) (CMIA) = Reactive (1.35) ( >= .05 is reactive)

SGPT =66 ( Range 16- 63 )
Abdominal scanning = NORMAL ( no swelling in liver)
HBV DNA quantitative anlaysis value = NORMAL ( below the range)

Sir Pls help me am worried a lot what;'s happening in my body

am in carrier state ?? if how to get out from this and my marriage is there pls give me suggestions in detail .. pls reply am acutely infected or am carrier of this virus???

Answered by Dr. Tushar Kanti Biswas (2 hours later)

Brief Answer:
HBV infection-carrier state

Detailed Answer:
Hi,

Thank you for your query. I can understand your concerns.
It seems that you are inactive HBV carriers. You are HBsAg positive.
Total antibodies to Hepatits B Core antigen(HBctotal)[CMIA] = Reactive(1.90) (>= 1.0 is reactive) but Anti-HBc IgM- Negative (0.01)-that indicates past infection.Over time, the replicative phase of chronic HBV infection gives way to a relatively nonreplicative phase -hence your HBV DNA quantitative anlaysis value = NORMAL ( below the range).You might have undergone seroconversion from HBeAg-positive to anti-HBe-positive. As a result you are HBeag NEGATIVE now.
Go for serum anti-HBe level and Anti-HBc IgG level.
Even in the so-called nonreplicative phase, HBV replication can be detected at levels of 103 virions with highly sensitive amplification probes such as the polymerase chain reaction (PCR); below this replication threshold, liver injury and infectivity of HBV are limited to negligible.
Consult a Gastro-enterologist and remain under periodic observation.Don't donate blood.

Regards

Dr. T.K. Biswas M.D. XXXXXXX

Above answer was peer-reviewed by : Dr. Prasad

Follow up: Dr. Tushar Kanti Biswas (49 minutes later)

pls am requesting u can u answer me HBSAG can be made negative if anti-HBe level and Anti-HBc IgG level serum reports are normal?? or life long i have to carry this virus? how to cure this beacuse in Hbsag (ELISA method) it's negative.
so pls tell me i want to know how can become -ve for this virus?

Answered by Dr. Tushar Kanti Biswas (1 hour later)

Brief Answer:
Inactive hepatitis B carriers & clearance of HBsAg

Detailed Answer:
Hi,

Thank you for your query. I can understand your concerns.
Anti-HBc IgG is advised in your case, as generally in persons who have recovered from hepatitis B, anti-HBc (IgG) persist indefinitely.
Anti-HBe level is advised to assess possible seroconversion from HBeAg-positive to anti-HBe-positive.
You are HBsAg positive and HBeAg negative;now if you are Anti-HBc (IgG) is positive,and Anti-HBe is also postive,it will indicate low infectivity/HBeAg–negative hepatitis B or inactive hepatitis B carriers.
The prognosis of the inactive HBsAg carrier state is usually benign. Long-term follow- up (up to 18 years) of these carriers has indicated that the vast majority show sustained biochemical remission and very low risk of cirrhosis.
Inactive hepatitis B carriers does not require any anti-viral therapy but to remain under periodic evaluation for re-activation.
Some carriers eventually become HBsAg negative spontaneously and develop anti-HBs (protective antibody).Clearance of HBsAg has been reported to be higher in women.So be optimistic.

Regards

Dr. T.K. Biswas M.D. XXXXXXX

Note: For more detailed guidance, please consult an Internal Medicine Specialist, with your latest reports. Click here..

Above answer was peer-reviewed by : Dr. Neel Kudchadkar