Brief Answer:
Information

Detailed Answer:
Hello and welcome,

AIP stands for acute intermittent porphyria. I doubt that is what you were tested for - did you make a typo perhaps? Please write out the full name of the test. Also what do you mean by FLY? These aren't standard medical abbreviations so I want to clarify.

Also, have your labs been normal in the past, and are you taking any medicaitons?

Thanks - I'll write back with information after you clarify.

---

Brief Answer:
Information

Detailed Answer:
Thank you for the additional information. Your alkaline phosphatase is elevated and if your liver enzymes were ok, then here is what I would look into next:

1. As your elevation is not more than 2 times the upper end of normal, if your Alk Phos test was not done fasting, then it should be repeated when fasting.

2. If the test was done fasting, and your GGT liver enzyme was normal (which I will assume as you said your liver enzymes were all normal), then the increase may be bone related rather than liver/gall bladder related.

3. The initial tests for evaluating bone related increases in alkaline phosphatase are measurement of serum calcium, thyroid hormone (TSH, free T4) to look for hyperthyroidism (I've noted your family history on this), parathyroid hormone, 25-hydroxy vitamin D, and imaging with bone scintigraphy. If it turns out that your Vitamin D level is low, it isn't necessary to precede with a more elaborate work up such as bone scintigraphy. If thyroid or parathyroid hormone is abnormal, then referral to an endocrinologist is next.

You mentioned that you are taking a statin - that can cause mild alkaline phosphatase elevations (should be less than 2x the upper end of normal) but typically this is seen in conjunction with elevated liver enzymes. Still, if other tests turn out normal, it is something to consider.

So that would be how to precede. I hope this information is helpful, and sorry for the wait.

---