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Dr. Andrew Rynne

Family Physician

Exp 50 years

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Hi , This query is for Hematologist only. please pass

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Dr. Shailja Puri

Pathologist and Microbiologist

Practicing since :2006

Answered : 7395 Questions

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Posted on Mon, 17 Dec 2018 in Blood Disorders
Question: Hi , This query is for Hematologist only. please pass this to Hematologist only. please find attached report for my wife . this is recently done HPLC report and her doctor asked us to check with hematologist regarding significance of the increased HBF for conception for my wife. I have also emailed the report at YYYY@YYYY in case you are not able to view attached report. thanks
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Answered by Dr. Shailja Puri 58 minutes later
Brief Answer:
Kindly,upload CBC and HPLC report.Advised vitamin B12 and folic acid levels

Detailed Answer:
Hello,
Thanks for posting your query on HealthcareMagic.
HPLC - High performance liquid chromatography is the method used to detect different types of hemoglobins or hemoglobin variants in our blood.
The major concern of HPLC for hemoglobin variant study before conception is to detect any abnormally elevated hemoglobin in blood which may be transmitted to unborn child and cause diseases like thalassemia.
Elevated Hb F is associated with thalassemia.
However, before labeling anyone as thalassemia carrier, it is important to rule out vitamin B12 and folic acid deficiency.
I would request you to upload a complete blood count (CBC) report and HPLC report for hemoglobin variant since no report is attached with the query.
In addition, do get vitamin B12 and folic acid assay to assess their adequacy.
In case vitamin B12 and / or folic acid are low, supplements need to be taken for deficiency and then again HPLC for hemoglobin variant needs to be performed.

Thanks and take care
Dr Shailja Puri


Above answer was peer-reviewed by : Dr. Prasad
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Follow up: Dr. Shailja Puri 1 hour later
thanks doctor . I had already mailed HPLC REPORT of my wife earlier at YYYY@YYYY because if I attach here it won't be visible due to some technical issue but no problem I am sending you aCBP , vitamin b12 and HPLC REPORTS for my wife. all these test are done very recently. and we already visited gynaecologist who has asked my wife to start folvite active tablet daily(for folic acid and vitamin b12). gynaecologist has advised to check with hematologist for increased HBF . I will confirm you once I send all these reports in mail
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Follow up: Dr. Shailja Puri 8 minutes later
i have shared all Reports in email at YYYY@YYYY just now. please check and confirm
doctor
Answered by Dr. Shailja Puri 35 minutes later
Brief Answer:
Hb F is only mildly elevated and is normal for age of the subject.

Detailed Answer:
Hello and welcome again,

I have gone through the HPLC and CBC report.
The haemoglobin is within range for age.

HPLC shows mild elevation of Hb F which is normal for age and may decrease with increasing age.
The risk of hemoglobinopathies like thalassemia carrier state or disease state is negligible. You may repeat HPLC after completion of vitamin B12 and folic acid supplementation.

Vitamin D supplementation is also required since levels are quite low.

Thanks and take care
Dr Shailja Puri

Above answer was peer-reviewed by : Dr. Arnab Banerjee
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The User accepted the expert's answer

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