Question: I am 77 yrs. old retired physician taking 300-600mg of Gabapentin (2months) per day. I am also taking Coumadin, Plavix, Lovaza, Deplin, Atorvastatin, Lexapro, and Donepezil. The Deplin (1 month) and Donezil (i week) are very recent medications. My question is, are any of these medications especially the more recent ones Deplin, Donezil, and Gabapentin statistically significant in interfering with either the Coumadin or Plavix? IS THERE ANY HISTORICAL DATA THAT ARICEPT OR IT'S GENERIC FORMULATION (DONEPEZIL) CAUSING ACUTE HYPERTENSION? ON MONDAY, 7 APRIL MY BP WAS 119/75. I STARTED THE DONEPEZIL 5MG ON SUNDAY, 6 APRIL. ON THE FOLLOWING THURSDAY, 10 APRIL MY BP WAS 166/88, ON FRIDAY 11 APRIL IT WAS 200/90s @11:00 AM. A 2ND READING IN THE OPPOSITE ARM WAS 188/90. AT 4:30 PM ON FIRDAY IT WAS 174/80. ON SATURDAY 12 APRIL THE BP WAS 166/80s. NO BP WAS PERFORMED ON SUNDAY THE 13TH. TODAY (MONDAY) THE 14TH OF APRIL THE BP WAS 141/83-R ARM AND 139/89-L ARM. THUS, ON THE 6TH DAY OF TAKING THE DONEZEPIL I HAD DEVELOPED ACUTE HYPERTENSION. I HAD ABSOLUTELY NO SYMPTOMS INCLUDING NO HEADACHES!!! I HAVE NO HISTORY OF RENAL, LIVER, ENDOCRINE NOR ANY CHRONIC DISEASE ISSUES. I DID DEVELOP DIARRHEA ONCE AT THE 2ND OR 3RD DAY OF THE DONEZEPIL, AND I AM AWARE THIS IS A KNOWN SIDE EFFECT OF TAKING DONEZEPIL. I WOULD APPRECIATE A PHARMACOLOGIST MD ANSWERING THIS QUESTION, I AM ASSUMING THE DONEZEPIL WAS THE ACUTE HYPERTENSIVE ISSUE AND WAS RESOLVED BY STOPPING THIS DRUG? XXXXX