Get your health question answered instantly from our pool of 18000+ doctors from over 80 specialties

189 Doctors Online
Doctor Image
Dr. Andrew Rynne

Family Physician

Exp 50 years

I will be looking into your question and guiding you through the process. Please write your question below.

Can a person with MTHFR mutation donate a kidney?

Answered by
Dr. Diptanshu Das


Practicing since :2005

Answered : 3759 Questions

Posted on Thu, 23 Mar 2017 in Kidney Conditions
Question: i have been diagnosed with mthfr and factor five, my mother needs a kidney. what are the risks for me and her?
Answered by Dr. Diptanshu Das 2 hours later
Brief Answer:
Risks enumerated

Detailed Answer:
Thanks for asking on HealthcareMagic.

I have gone carefully through your query and understand your concerns. I hope that you are talking about C677T MTHFR mutation and factor V Leiden mutation. I infer that you are talking about donating a kidney to your mother. The main thing that concerns us in case of a kidney transplant is the Major Histocompatibility Complex (MHC) and human leukocyte antigen (HLA) match. Since this is a case of mother and offspring, there is already a 50% match in the gene pool and so a graft rejection is less likely. Your having C677T MTHFR mutation and factor V Leiden mutation would not complicate the matter provided that your kidney(s) are in otherwise good health.

Kidney donation involves major surgery, and there are risks, including bleeding and infection for both you and your mother. You would need a period of time for recovery. With time, your remaining kidney will enlarge as it takes on additional blood flow and filtration of wastes. Hopefully things would be fine. Your mother bears the additional risks like the possibilities of failure of the donated kidney, rejection of the donated kidney or the side effects of anti-rejection medication.

Let me know if you want to know anything specific and I will guide you further.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

The User accepted the expert's answer

Share on
Question is related to
Diseases and Conditions
Medical Procedures
Medical Topics ,   ,  

Recent questions on  Kidney transplantation

doctor1 MD

I had surgery for kidney cancer 8 years ago. They removed part of my right kidney. I am also diabetic. For the last week I have been having pain in my right leg where it is hard to lift my leg and it feels like it will give out some times when I am walking. Can this be related to my kidneys?

doctor1 MD

My daughter is a transplant patient. She has had her kidney for 15 years and has been on azathiaprine and prednisolone for some time now. She recently started taking Microgynon 30 (one month) and her creatin has crept up. All her other results are completely normal. Is it possible the Microgynon is affecting her results?

doctor1 MD

Hi, I am a kidney transplant patient from last 2 year. Just 1 week earlier i started running miles. After 1 week my both ankles started paining because of some kind of twist. Doctor has told me to take zerodol p twice a day. Please let me know if it will have anyother effect on me. Thanks, Sunny

doctor1 MD

Not sure if this is a coincident that everytime I feel like a cold is approaching, feel ill, I notice blood in my urine. My mother has had a kidney transplant, and I am aware of the inheritance. So far, doctors can not find out the cause of blood in urine, I am considered healthy. I am in doubt, is this common for women under the age of 40?

doctor1 MD

My daughter is overseas and has asked about a rash she has developed: First one, now two, salmon-colored slightly raised patches of approximately 2 and 3 centimeters, respectively. One is just anterior to her left axilla, the other is on her...

doctor1 MD

Ii had a liver and kidney transplant in July. Doing great. Will I ever be able to have a glass of wine again? I never was much of a drinker. I had polycystic kidney and liver.

doctor1 MD

I'm a 66 year old male with a kidney transplant and triple by-pass. Trying to lose some weight, 210lbs. 6 ft tall, Currently on D3 1000iu and wondering about upping that dose to 5000iu and adding K2 90mmg. Current meds are fluoxetine, allopurinol...