Can Premarin vaginal cream be applied after removal of uterus due to uterine cancer?
Use progesterone along with estrogen
The use of Premarin is controversial in uterine cancer patients. Indirect evidence exists that progesterone over expresses wild type of p53 gene preventing recurrences if ER PR [receptors] are positive.
Our practice is prescribe Tablet Premarine-0.625 mg per day continuously [vaginal cream may also be used] and progesterone [Megestrol-10 mg] from date 1 to date 14 of every month.
This is because patients may need estrogen [premarin] as their ovaries are removed during treatment of uterine cancer [hormone dependant tumor]. But this may stimulate any endometrial tissue [although uterus is removed there may be chance of conversion of tissue to endometrium by process called metaplasia] leading to chance of recurrence.
To counter this action megestrol is given-recommended minimum for 14 days every month.
In a nutshell, you may use premarin along with progestrone. Discuss with your treating doctor.