I was diagnosed with extrapulmonary TB in September 2010 while previously treated for sarcoidosis. I do have granulomas. After 5weeks on Rifafour e-275, I actually feel even just as bad, but for the shivers. I suffer cracking headaches in the morning and back acke. My left backside (i think it is the spleen) aches constantly and is tender and painful when sitting against a chair. Couldmy spleen be infected an d what else. Im female 54yrs of age. Very depressed feelings bug me constantly- as if I dont care at all.