Hello, Pregnedoxin contains Meclizine and caffeine. Meclizine is an antihistamine and is used as anti-emetic in the vomiting of pregnancy. Meclizine is a category B drug and this means that it should be used in pregnancy with caution though no adverse effects on the fetus have hitherto been reported; if the benefits outweigh the risks. The drug should be taken on empty stomach early in the morning before she gets up from the bed. She can take dry fruits, fruit juices and whatever she can tolerate without vomiting. She should avoid heavy foods, oily and fried foods. Take care.