Hi, Duphaston is a medication that contains dydrogesterone, a synthetic hormone that is similar to the natural hormone progesterone. It is commonly used to treat menstrual disorders, infertility, and menopausal symptoms. Acne and premenstrual spotting are common side effects of Duphaston. However, there is no evidence to suggest that Duphaston causes brain freeze syndrome, which is a type of headache characterized by a sudden, intense, stabbing pain in the head. While Duphaston is generally considered safe and well-tolerated, like all medications, it can cause side effects. If you have concerns about your symptoms or the medication you are taking, it is best to discuss them with your healthcare provider. They can evaluate your condition and guide the appropriate treatment options. Take care. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Priyanka, General & Family Physician