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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Does Lamotrigine Cause Drop In Amniotic Fluid Index?

Hi doctor
i have some doubts regarding my preganancy... now i am 26 weeks pregnant.. and i intially had liqour or AFI 12 cms and it was reduced to 8 during my 24 the week.. so then i was on medication with ARG 9 and some other like iron, ca etc... and i have the health problem of epileptic sezuire and i use lamitrogine for that.... i want to know whether my Afi is reduced due to lamotrogine or does my baby have any birth defects? i just want know what can i do to rule out this?
Fri, 27 Nov 2015
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OBGYN 's  Response
Hi,

Lamotrigine is known to cause birth defects , which can present with reduced levels of liquor. but since you have epileptic seizures it is very important that you continue the medication throughout pregnancy.
To check the baby for defects, we need to get a detailed malformation scan by a fetal medicine specialist. Neural tube defects, heart anomalies, kidney defects and defects in mouth are more common in women on epileptic medications.
Also undergo a fetal 2D echo scan to see for heart abnormalities. Ultrasound doppler studies to assess the growth of the baby from 28 weeks will be required.

Hope this helps.
Regards.
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Does Lamotrigine Cause Drop In Amniotic Fluid Index?

Hi, Lamotrigine is known to cause birth defects , which can present with reduced levels of liquor. but since you have epileptic seizures it is very important that you continue the medication throughout pregnancy. To check the baby for defects, we need to get a detailed malformation scan by a fetal medicine specialist. Neural tube defects, heart anomalies, kidney defects and defects in mouth are more common in women on epileptic medications. Also undergo a fetal 2D echo scan to see for heart abnormalities. Ultrasound doppler studies to assess the growth of the baby from 28 weeks will be required. Hope this helps. Regards.