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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Acne. On Minocycline. Joint Pain, Itchy Lumps, Swollen Toes, Fingers. Took Benadryl. Serious?

I ve been on minocycline for about two weeks now for acne, today I woke up with severe joint pain to the point where I could barely walk. And now right before bed I have large lumps on my legs that itch like crazy I m guessing hives. My fingers and toes are swollen. I took Benadryl. I was just wondering if this is serious and if I should go to the ER.
Mon, 29 Apr 2013
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Dermatologist,  's  Response
hi, thanks for your query
You seem to have probably developed lupus like syndrome with minocycline characterised by joint pain, stiffness or swelling of joints, fever, muscle pain, skin rash, inflammation of blood vessels.

Benedryl is antihistaminic will help in reduction of the rash and itching so it is helpful but it is better to rule out any serious side effects or minoxidil.

You must stop taking the tablets and contact ER as early as possible.

Hope this helps you
Wishing you a speedy recovery
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Acne. On Minocycline. Joint Pain, Itchy Lumps, Swollen Toes, Fingers. Took Benadryl. Serious?

hi, thanks for your query You seem to have probably developed lupus like syndrome with minocycline characterised by joint pain, stiffness or swelling of joints, fever, muscle pain, skin rash, inflammation of blood vessels. Benedryl is antihistaminic will help in reduction of the rash and itching so it is helpful but it is better to rule out any serious side effects or minoxidil. You must stop taking the tablets and contact ER as early as possible. Hope this helps you Wishing you a speedy recovery