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What Causes Elevated Bilirubin Levels?

Posted on Fri, 17 Jun 2016

Question: Whas the difference between gilberts syndrome and crigler najjir 2? I have elevated bilirubin at times of not eatting... Im in the range of 1.2-2.5... Once i was at 3.0 but didnt eat for about 20 hours...

I cant seem to settle my mind on giberts syndrome because it seems as if crigler najjor 2 could be possible... Please if i can get lab references , age of typical diagnosis of criggler it would be extremely helpful...

I was recently diagnosed with gilberts but it was done with one blood test by my gastro and was told over the phone... Please help to give me something tangeable so i can stay away from the internet ...

Answered by Dr. Dr. Muhammad Sareer Khalil (3 hours later)

Brief Answer:
Explained

Detailed Answer:
Hello and Welcome

I appreciate your concern

In glucoronyl transferase deficient individuals, jaundice occurs which is harmless. Its know as XXXXXXX syndrome and no further tests are needed.

In criglar najjar type 2 there is moderate GT deficiency but it can potentially lead to increase unconjugated bilirubin and kernicterus in child and be fatal.

Based on your description, its most consistent with XXXXXXX

If appropriate, Kindly upload the test results you mentioned to comment further

Wishing you best of health

Thanks

Let me know if you have any query

Please consult your doctor before deciding on any further course of action.

For future follow up / correspondence you may ask me directly at the link given below

http://doctor.healthcaremagic.com/Funnel?page=askDoctorDirectly&docId=68107

Dr. M.S. Khalil

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

Follow up: Dr. Dr. Muhammad Sareer Khalil (16 minutes later)

These are all seperate labs... My question as well as the last is when in is criggler type 2 discovered .. i want to know if this is the benign gilberts or should i start looking into medication for myself ... I know criggler type 1 is figured out at birth so i know i dont have that but my elevated bilirubin started in 2008 and now all these labs were done this year .. I just want to know if i should seek another opinion .. I have 3 kids and two of three had jaundice as babies but went down as normal..

Answered by Dr. Dr. Muhammad Sareer Khalil (2 hours later)

Brief Answer:
Explained

Detailed Answer:
Hello and welcome

Your concern is appreciated

Gibert syndrome is benign genetic liver disorder in which its unable to process bilirubin due to decrease activity of an enzyme called UGT1A1. Its an autosomal recessive trait. People with gilbirt syndrome has reduced levels of this enzyme. People with this disease have one third activity of this particular enzyme. Some times there is no symptoms while some may experience slight yellowish discoloration of skin, in some jaundice is only apparent when triggered by condition like dehydration, stress, exertion, fasting, infection or alcohol consumption. There is fluctuating levels of bilirubin.
Other similar disease is criglar najjar type two , in this there is persistent yellow skin . There is decrease activity of this enzyme UGT1A1 but its even more less than its in gilberts. There is no clinical consequence. Type one is too fatal it presents on infancy and requires aggressive treatment. XXXXXXX requirea no treatment and its harmless condition. XXXXXXX is determined to be there when there is hyperbilirubinemia in the abcesnce of hemolysis.

Hope it helps
Thanks.

Dr M.S Khalil

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

Follow up: Dr. Dr. Muhammad Sareer Khalil (12 minutes later)

So your opinion on my test are? Let me know

Answered by Dr. Dr. Muhammad Sareer Khalil (4 minutes later)

Brief Answer: XXXXXXX

Detailed Answer:
Hello again

Based on these labs, it's most likely XXXXXXX syndrome.

Thanks

Dr M.S Khalil

Note: For more detailed guidance, please consult an Internal Medicine Specialist, with your latest reports. Click here..

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar