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What Causes Consecutive Miscarriages When Diagnosed With MTHFR Genetic Defect?
Question: Hi
I am 38 years old. 1 successful live birth and 3 consecutive miscarriages since (all prior to 7 week heartbeat).
I am MTHFR 1298c homozygous.
No Western doctors in Australia believe in it and say "keep trying". At my age I think that's very dangerous.
I have switched prenatals to one with L-Methylfolate; but where I am really torn is with regards to blood thinners.
1. Do I need them?
2. If so, which ones? (Lovenox? Baby Aspirin? Both?) And when?
Anything else I should do to ensure a healthy baby next time?
XXXX
I am 38 years old. 1 successful live birth and 3 consecutive miscarriages since (all prior to 7 week heartbeat).
I am MTHFR 1298c homozygous.
No Western doctors in Australia believe in it and say "keep trying". At my age I think that's very dangerous.
I have switched prenatals to one with L-Methylfolate; but where I am really torn is with regards to blood thinners.
1. Do I need them?
2. If so, which ones? (Lovenox? Baby Aspirin? Both?) And when?
Anything else I should do to ensure a healthy baby next time?
XXXX
Brief Answer:
both lovenox and baby aspirin would be required
Detailed Answer:
Hello,
Thanks for the query to hcm,
Being MTHFR homozygous can easily cause homocysteine levels to rise and elevated homocysteine can cause inflammation in blood vessels and increases the risk of microscopic clot formation. This can invariably lead to early first trimester losses. it would be important to learn your basal serum homocysteine levels as on date and if high then you shall require VITAMIN B12 injection 10mg ON ALTERNATE day for 3 doses to bring the levels down.
Also would be required the use of low molecular weight heparin or LMWH 40/60mg( depending on your weight) from the day the foetal heart beat arrives daily till a week post delivery to avoid any thrombogenic event. Pregnancy itself is a thrombogenic state, for info. So best would be to use baby aspirin and LOVENOX , both once the heart beat arrives. Also its best to continue L-5 METHYLTETRAHYDROFOLATE TABS 5MG ( ATLEAST ) daily till at least 14 weeks of gestation and 3 months prior during pre-conceptional phase.
Regards
both lovenox and baby aspirin would be required
Detailed Answer:
Hello,
Thanks for the query to hcm,
Being MTHFR homozygous can easily cause homocysteine levels to rise and elevated homocysteine can cause inflammation in blood vessels and increases the risk of microscopic clot formation. This can invariably lead to early first trimester losses. it would be important to learn your basal serum homocysteine levels as on date and if high then you shall require VITAMIN B12 injection 10mg ON ALTERNATE day for 3 doses to bring the levels down.
Also would be required the use of low molecular weight heparin or LMWH 40/60mg( depending on your weight) from the day the foetal heart beat arrives daily till a week post delivery to avoid any thrombogenic event. Pregnancy itself is a thrombogenic state, for info. So best would be to use baby aspirin and LOVENOX , both once the heart beat arrives. Also its best to continue L-5 METHYLTETRAHYDROFOLATE TABS 5MG ( ATLEAST ) daily till at least 14 weeks of gestation and 3 months prior during pre-conceptional phase.
Regards
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Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
Answered by
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