Hi there ~

I understand your concerns for your mother. I ran a medicine interactions for the medications that your mother has been on and I found the following:

Using furosemide together with metFORMIN may increase the effects of metFORMIN, which may lead to a life-threatening condition called lactic acidosis This can cause weakness, increasing sleepiness, slow heart rate, muscle pain, shortness of breath, stomach pain, feeling light-headed, and fainting. Talk with your doctor before using furosemide while you are using metFORMIN. You may need a dose adjustment and you may need to check your blood sugar more often. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Before taking spironolactone, tell your doctor if you also use metFORMIN. Spironolactone can cause high blood sugar and interfere with glucose control. You may need a dose adjustment and you may need to check your blood sugar more often if you take both medications. Spironolactone can also increase the risk of lactic acidosis while you are using metFORMIN. Symptoms of lactic acidosis include unusual muscle pain and weakness, trouble breathing, fast or uneven heart rate, nausea, vomiting, stomach pain, and numbness or cold feeling in your arms or legs. Call your doctor at once if you have any of these symptoms, even if they are only mild. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.

Furosemide may reduce the effects of glimepiride in lowering your blood sugar. Talk with your doctor before using these medications together. You may need a dose adjustment or more frequent monitoring of your blood sugar if you have been using glimepiride and are starting treatment with furosemide. Likewise, if your glimepiride dose has been adjusted during treatment with furosemide, the dose may need to be readjusted after you discontinue furosemide. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

It seems like your mothers blood sugar has not been adequately controlled over time as she has an AbA1C higher than 7 i.e. 8.1. I am glad that the RA tests are normal and she is taking the B12 supplementation as you mention in your current medications list. The problem with breathing with weather changes sounds like asthmatic allergies and treating the allergy with monteleukast or loratidine should do the trick. I also am glad that the WBC counts are normal and your mother is fighting off any potential infection very effectively. The swelling of the hands and feet might be related to a poor cardiac function. I hope you get her 2D Echocardiogram done or an angiogram done to rule out any cardiac pathology causing the situation and also any problems with the ejection fraction of the heart, which is very important. I hope this helps.

The anxiety around all these issues and the caregiver burnout might be huge. I hope you seek help in an online forum and am glad you brought this up here.

I hope this helps.

Take care and have a lovely day!

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Hi there ~

Mirtazapine 7.5 mg given at night after meals along with twice a day lupizyme should increase her appetite and also have her sleep well. I hope it helps. There is no medication without side effects. I am hoping that even if she has a side effect to these medications she will sleep it off, since mirtazapine has a slightly sedative effect.

I hope this helps. Take care and have a lovely day!

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