I am a 57 y.o. woman with some prehypertension, slightly elevated cholesterol, no diabetes. I had a severe bout of depression and anxiety recently, which I am being treated for, but I have since been feeling more cognitively slow, and have some tremors in my hands at times, and some muscular twitches in various parts of my body. I had an MRI to rule out MS (which my mother had), and they found microvascular ischemic changes bilaterally in my brain. The neurologist said this amount was pretty average for my age. I also recently had a cardiac calcium score done - it is 1. Should I be concerned about this MRI? At the height of my depression, I was in bed for 3 days with severe headaches (I also have cervical spine degeneration) but I actually felt like I had had a mini-stroke. Has my brain had little mini-strokes, thus the ischemic changes?