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What Causes Weak Legs In A Patient With Parkinson S Disease?
My father is suffering from parkinson since 2001.Now he is taking medicine like-sundopa 110mg-TID , pacetane 2mg-OD , amantrel 100mg-BID , rasalact 0.5mg-OD(at night).But for the last 4 days he is feeling loss of power in his legs as well as in his hands. His body is also tremoring very frequently.Please advice.
Mon, 24 Nov 2014
Hi,
Thank you for your query. I can understand your concerns.
Parkinson's Disease typically does not cause muscle weakness .
Weakness of legs and hands experienced by your father is due to severe bradykinesia due to Levodopa (sundopa 110mg-TID) induced motor complications 'wearing-off effect'.
With continued treatment,the duration of benefit following an individual dose becomes progressively shorter . During such "off" periods they suffer severe parkinsonism (akinesia & tremoring very frequently).They can often be improved by dividing the levodopa into smaller but more frequent doses, or by converting to a slow release preparation. These patients may also be benefited by giving Levodopa with Selegiline. Selegiline, a type B monoamine oxidase inhibitor, inhibits catabolism of dopamine in the brain. This sometimes smoothes out the response to levodopa.
Regards
Dr. T.K. Biswas M.D.
Mumbai
Thank you for your query. I can understand your concerns.
Parkinson's Disease typically does not cause muscle weakness .
Weakness of legs and hands experienced by your father is due to severe bradykinesia due to Levodopa (sundopa 110mg-TID) induced motor complications 'wearing-off effect'.
With continued treatment,the duration of benefit following an individual dose becomes progressively shorter . During such "off" periods they suffer severe parkinsonism (akinesia & tremoring very frequently).They can often be improved by dividing the levodopa into smaller but more frequent doses, or by converting to a slow release preparation. These patients may also be benefited by giving Levodopa with Selegiline. Selegiline, a type B monoamine oxidase inhibitor, inhibits catabolism of dopamine in the brain. This sometimes smoothes out the response to levodopa.
Regards
Dr. T.K. Biswas M.D.
Mumbai
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