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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes Sudden Increase In ALT, AST And LDH?

My latest health check showed an increase in AST, ALT enzymes as well as LDH. Other levels were unchanged. AST went from 15 - 108 ALT went from 15 - 49 LDH went from 130 - 263. The only lifestyle changes between tests (1 year apart) were that I started exercising at a gym less than a week before the test, and also I had a bicycle crash 3 days before the test. Could those have an impact?
Fri, 21 Aug 2015
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General & Family Physician 's  Response
Hello,
Welcome to Health Care Magic. I read carefully your query and I understand your concern.
Your latest blood liver test ALT, AST and LDH has high level for their referential range it is clear and for you, you are unclear why? The reason can be the start of gym program workout one week before your check up, studies have shown that exercise especially muscular exercise (weightlifting) increased AST, ALT and LDH plus CK and myoglobin that you haven’t mentioned here so I didn’t know if you have done them or they were at their normal range, and does not affect bilirubin, γGT and ALP, they remain at normal range. The increase of this liver lab tests remains in these increasing status for at least 7 days post exercise.
Intensive muscular exercise, e.g. weightlifting has been considered as a cause of asymptomatic elevations of liver function tests.
This is the reason why you should say to your doctor that you have done lift exercise and when you have done this to help the right interpretation to your lab tests.
Hope this answers your question. If you have additional questions or follow up questions then please do not hesitate in writing to us. I will be happy to answer your questions.
Kind regard,
Dr .Marsida JANKO
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What Causes Sudden Increase In ALT, AST And LDH?

Hello, Welcome to Health Care Magic. I read carefully your query and I understand your concern. Your latest blood liver test ALT, AST and LDH has high level for their referential range it is clear and for you, you are unclear why? The reason can be the start of gym program workout one week before your check up, studies have shown that exercise especially muscular exercise (weightlifting) increased AST, ALT and LDH plus CK and myoglobin that you haven’t mentioned here so I didn’t know if you have done them or they were at their normal range, and does not affect bilirubin, γGT and ALP, they remain at normal range. The increase of this liver lab tests remains in these increasing status for at least 7 days post exercise. Intensive muscular exercise, e.g. weightlifting has been considered as a cause of asymptomatic elevations of liver function tests. This is the reason why you should say to your doctor that you have done lift exercise and when you have done this to help the right interpretation to your lab tests. Hope this answers your question. If you have additional questions or follow up questions then please do not hesitate in writing to us. I will be happy to answer your questions. Kind regard, Dr .Marsida JANKO