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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes Secondary Polycythemia?

My Aunt has polycythemia secondary (non-vera) I m trying to help her find out more information about it. The doctor s don t seem to know much of what causes it. She is having a pint of blood drawn every other month when her count is over 18. However, now they want her number 12 and under. Her numbers this last year have been between 15.8 and 19.3
Tue, 26 Dec 2017
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Pathologist and Microbiologist 's  Response
Hello. Thanks for asking on Healthcaremagic. Polycythemia is persistent increased rbcs and hence increased hemoglobin levels in the blood. It could be primary ie Vera or secondary to certain causes. Polycythemia Vera has low erythropoietin levels and on cytogenetics Jak2 mutation is found. In secondary Polycythemia underlying causes may be those causing chronic hypoxia which increase erythyopoietin production like sleep apnea, obesity hypo ventilation syndrome, copd, testosterone replacement therapy, smoking etc. Epo secreting tumors like hepatocellular CA, renal cell CA, adrenal adenoma could also cause it. High rbc count causes blood flow to be sluggish in brain and other essential organs causing symptoms like impaired alertness, dizziness, headaches, thrombosis, stroke, myocardial infarction, DVT. It is essential to find out the underlying cause and treat it to relieve secondary Polycythemia. Hope the doctor has checked erythyopoietin levels before labeling it as secondary. Otherwise regular blood removal is advised to keep hb from rising too much. Kindly look for a cause and treat it. Thanks.
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What Causes Secondary Polycythemia?

Hello. Thanks for asking on Healthcaremagic. Polycythemia is persistent increased rbcs and hence increased hemoglobin levels in the blood. It could be primary ie Vera or secondary to certain causes. Polycythemia Vera has low erythropoietin levels and on cytogenetics Jak2 mutation is found. In secondary Polycythemia underlying causes may be those causing chronic hypoxia which increase erythyopoietin production like sleep apnea, obesity hypo ventilation syndrome, copd, testosterone replacement therapy, smoking etc. Epo secreting tumors like hepatocellular CA, renal cell CA, adrenal adenoma could also cause it. High rbc count causes blood flow to be sluggish in brain and other essential organs causing symptoms like impaired alertness, dizziness, headaches, thrombosis, stroke, myocardial infarction, DVT. It is essential to find out the underlying cause and treat it to relieve secondary Polycythemia. Hope the doctor has checked erythyopoietin levels before labeling it as secondary. Otherwise regular blood removal is advised to keep hb from rising too much. Kindly look for a cause and treat it. Thanks.