hi sir/madam, Thanks for your question on Healthcare Magic. It seems that you may be having chronic idiopathic urticaria. You consult dermatologist to have investigations to rule out any precipitating cause. If no cause is found, then it may be labled as chronic idiopathic urticaria. Fexofenadine 180 mg daily or desloratadine 5 mg daily may be taken for long time. Hydroxyzine HCL 25 mg may be taken at night. For your itchy palms I would recommend you to apply topical steroid like clobetasol propionate cream on the affected areas twice daily along with frequent and liberal application of a moisturising cream containing white soft paraffin on the entire hands 3-4 times in a day. Also take antihistaminic like tablet Cetrizine 10 mg once or twice daily depending on the intensity of itching. In case the condition doesn t improve in 4-5 days take a short course of oral steroids like tablet prednisolone 10 mg once daily for 7-10 days. Consult your doctor for further treatment. hope this was helpful. have a healthy day.