Hello! Thank you for your question on HCM! I understand your concern. I think that the rash may be caused by two main problems: an allergic reaction to epilim or a hematological problem and low immunity caused by avastin. The first is the most possible. Avastine would typically cause red pinpoins on the skin or redness but not itchy rash. I would recommend to have a valproate plasma level and a full blood work, liver function tests. I would also recommend to switch to another anticonculsivant drug like Levetiracetam, which has no interactions with avastine and is effective for different types of seizures. Hope to have been of help! Greetings! Dr. Abaz Quka