Hello Dear. By your history you said that you do not have diabetes (glucose problem). Hence possibility of diabetic neuropathy is ruled out. Arthritis may cause pain around knee joint. But pain in upper leg and muscles points to some other pathology. You might be having nerve entrapment or pinched nerve as suggested by your doctor. A pinched nerve occurs when there is compression (pressure) on a nerve. The pressure may be the result of repetitive motions. Or it may happen from holding your body in one position for long periods, such as keeping elbows bent while sleeping. Nerves are most vulnerable at places in your body where they travel through narrow spaces but have little soft tissue to protect them. Nerve compression often occurs when the nerve is pressed between tissues such as: 1. Ligament 2. Tendon 3. Bone For example, inflammation or pressure on a nerve root exiting the spine may cause neck or low back pain. These are some of the more common symptoms of compressed nerves: 1. Pain in the area of compression, such as the neck or low back 2. Radiating pain, such as sciatica or radicular pain 3. Numbness or tingling 4. Pins and needles or a burning sensation 5. Weakness, especially with certain activities Sometimes symptoms worsen when you try certain movements. Treatment for Pinched Nerves: How long it takes for symptoms to end can vary from person to person. Treatment varies, depending on the severity and cause of the nerve compression. You may find that you benefit greatly from simply resting the injured area and by avoiding any activities that tend to worsen your symptoms. In many cases, that s all you need to do. If symptoms persist or pain is severe, see your doctor. You may need one or more types of treatment to shrink swollen tissue around the nerve. In more severe cases, it may be necessary to remove material that s pressing on a nerve, such as: 1. Scar tissue 2. Disc material 3. Pieces of bone Treatment may include: 1. NSAIDs. Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, ibuprofen, or naproxen may reduce swelling. 2. Oral corticosteroids. These are used to reduce swelling and pain. 3. Narcotics. These are used for brief periods to reduce severe pain. 4. Steroid injections. These injections may reduce swelling and allow inflamed nerves to recover. 5. Physical therapy. This will help stretch and strengthen muscles. 6. Splint. A splint or soft collar limits motion and allows muscles to rest for brief periods. 7. Surgery. Surgery may be needed for more severe problems that don t respond to other types of treatment. Work with your doctor to find the best approach for treating your symptoms. Hope i have answered your question. Feel free to contact me if you have any more questions. I ll be glad to help you. All the best With warm regards Dr Sanjay Kini