I had a right total knee repalcement Sept. 17 -for 4 months »i did the therapy »(exercises every day with a trained nurse in my home for one hour «ONE WEEK AFTER THE SURGERY i started having muscle spasms from my knee downward to my toes every two to three minutes - at night only- no pain with the spasms just jerking «««these spasms have increased starting at my hips down to my toes sometimes both sides left and right, sometimes only one side. my orthopedist surgeon says he has never encountered a patient like this before. my primary care physician recommended a muscle relaxant which did nothing except make me very tired the follwoing day right now my primary care physician has made an appointment with a neurologist as he is stumped- presently the only thing that lets me sleep at night is oxocodine which i try not to take too frequently. i had an epidural for the surgery, All blood tests regarding possible irregularities are normal. «I have taken quinine drinks for the spasms with no results. «i am 68 years old, very healthy otherwise, exercise regularly and maintain good nutrition. there is no pain or spasms whilst sitting or standing or walking - only at night after about an hour lying in bed. wish I could sleep standing up as then there are absolutely no spasms. thank you for your suggestions and comments e. prosser