ISCHEMIC HEART DISEASE RISK FACTOR Ischemic Heart Disease has been known to develop due to several risk factors such as having high cholesterol levels, diabetes mellitus and smoking. People who suffer from high blood cholesterol or hypercholesterolemia have a higher degree of risk for developing ischemia. Other risk factors that may cause Ischemic Heart Disease are hypertension, genetic and hereditary factors, menopause, and stress. I hope you happy with information. thank you .