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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes Excessive Thirst And Sweating While On Amoxicillin?

I just switched from Cefdiner to Amoxicillin for a sinus infection; prior to starting medicine I lost around five pounds, have had excessive night sweats and always thirsty (around 15 glassess water/day). Not eating much with antibiotic, still thirsty and still excessive sweating. Besides reducing water to perhaps help with night sweats, what else can I do.
Wed, 19 Apr 2017
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General & Family Physician 's  Response
I totally understand your concerns regarding the sweating issue.
The following points should be taken into consideration:
1- Sweating is one of the symptoms of infection, and according to the history you provided, you are suffering from a sinus infection. So sweating is not an unusal symptom in your case. Thirst is a feeling from your nervous system that indicates dehydration. If you are excessively sweating, you are losing water, you become dehydrated and hence you feel thirsty. One other clue to know if you are dehydrated is your urine output and urine color. If you notice that your urine is darker than usual and that you are giving less urine then this is also a sign of dehydration. In such case it is highly recommended to keep your water intake because dehydration can lead to severe electrolyte imbalances with a lot of complications and can lead to kidney injury. Your body needs water, so keep drinking. When the infection is over then you will stop losing water by sweating and your thirst will go away.

2- I just want to make sure that this a sinus infection. The fact that you were switched from an antibiotic to another is unusual, especially from a third generation cephalosporin such as cefdiner to a less broad spectrum antibiotic which is amoxicillin only. I prefer a revevaluation of your infection, make sure that the lungs are clear, rule out all the possible differentials associated with night sweating and loss of weight.

Best Regards
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What Causes Excessive Thirst And Sweating While On Amoxicillin?

I totally understand your concerns regarding the sweating issue. The following points should be taken into consideration: 1- Sweating is one of the symptoms of infection, and according to the history you provided, you are suffering from a sinus infection. So sweating is not an unusal symptom in your case. Thirst is a feeling from your nervous system that indicates dehydration. If you are excessively sweating, you are losing water, you become dehydrated and hence you feel thirsty. One other clue to know if you are dehydrated is your urine output and urine color. If you notice that your urine is darker than usual and that you are giving less urine then this is also a sign of dehydration. In such case it is highly recommended to keep your water intake because dehydration can lead to severe electrolyte imbalances with a lot of complications and can lead to kidney injury. Your body needs water, so keep drinking. When the infection is over then you will stop losing water by sweating and your thirst will go away. 2- I just want to make sure that this a sinus infection. The fact that you were switched from an antibiotic to another is unusual, especially from a third generation cephalosporin such as cefdiner to a less broad spectrum antibiotic which is amoxicillin only. I prefer a revevaluation of your infection, make sure that the lungs are clear, rule out all the possible differentials associated with night sweating and loss of weight. Best Regards